APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1-2μg/ml for 30 minutes at RT |
| Assay dependent |
|
Note :
IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
|
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant full-length human beta-Catenin (CTNNB1) protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CTNNB , CTNNB1 , MRD19 , armadillo , catenin beta 1 , beta Catenin , Catenin-β , β Catenin
Cellular Localization
Cytoplasm,Nucleus,Cytoskeleton,Cell junction,Adherens junction,Cell membrane,Microtubule organizing center,Centrosome,Spindle pole,Synapse
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Database
Research Area
DATA IMAGES
![Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954](/templates/default/js/lightbox/images/loading.gif "Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954")
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GTX17954 IHC-P Image
IHC-P analysis of human tonsil tissue using GTX17954 beta Catenin antibody [CTNNB1/2098].
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GTX17954 IHC-P Image
IHC-P analysis of human tonsil tissue using GTX17954 beta Catenin antibody [CTNNB1/2098].
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GTX17954 Protein Array Image
Analysis of Protein Array containing more than 19,000 full-length human proteins using Catenin, beta (CTNNB1) Mouse Monoclonal Antibody (CTNBB1/2098). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
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REFERENCE
There are currently no references for beta Catenin antibody [CTNNB1/2098] (GTX17954). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for beta Catenin antibody [CTNNB1/2098] (GTX17954). Be the first to share your experience with this product.
![Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954](/upload/website/prouct_img/small/GTX17954/GTX17954_20200115_IHC-P_1277_w_23060620_340.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954")
![Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954](/upload/website/prouct_img/small/GTX17954/GTX17954_20200115_IHC-P_1276_w_23060620_742.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954")
![Anti-beta Catenin antibody [CTNNB1/2098] used in Protein Array (Protein Array). GTX17954](/upload/website/prouct_img/small/GTX17954/GTX17954_20200115_Protein-Array_1979_w_23060620_765.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in Protein Array (Protein Array). GTX17954")
![Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954](/upload/website/prouct_img/normal/GTX17954/GTX17954_20200115_IHC-P_1277_w_23060620_340.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954")
![Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954](/upload/website/prouct_img/normal/GTX17954/GTX17954_20200115_IHC-P_1276_w_23060620_742.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in IHC (Paraffin sections) (IHC-P). GTX17954")
![Anti-beta Catenin antibody [CTNNB1/2098] used in Protein Array (Protein Array). GTX17954](/upload/website/prouct_img/normal/GTX17954/GTX17954_20200115_Protein-Array_1979_w_23060620_765.webp "Anti-beta Catenin antibody [CTNNB1/2098] used in Protein Array (Protein Array). GTX17954")